Title : Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy.

Pub. Date : 2010 Aug 15

PMID : 20814247






2 Functional Relationships(s)
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1 BubR1 knockdown in the presence of nocodazole induced an R1530-like phenotype, suggesting that BubR1 plays a key role in polyploidy induction by R1530 and could be exploited as a target for designing more specific polyploidy inducers. Nocodazole BUB1 mitotic checkpoint serine/threonine kinase B Homo sapiens
2 BubR1 knockdown in the presence of nocodazole induced an R1530-like phenotype, suggesting that BubR1 plays a key role in polyploidy induction by R1530 and could be exploited as a target for designing more specific polyploidy inducers. Nocodazole BUB1 mitotic checkpoint serine/threonine kinase B Homo sapiens