Protein Name BUB1 mitotic checkpoint serine/threonine kinase B
Organism Homo sapiens
Gene ID 701
Gene Symbol

BUB1B

UniProt O60566 (BUB1B_HUMAN)
Relationships Total Number of functionally related compound(s) : 111
Total Number of Articles : 127
Description

BUB1 mitotic checkpoint serine/threonine kinase B

Gene Summary

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]

synonyms
  • mitotic checkpoint serine/threonine-protein kinase BUB1 beta
  • BUB1B, mitotic checkpoint serine/threonine kinase
  • MAD3/BUB1-related protein kinase
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Properties