Title : Differential mechanisms for the inhibition of human cytochrome P450 1A2 by apigenin and genistein.

Pub. Date : 2010 Jul-Aug

PMID : 20806393






1 Functional Relationships(s)
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1 In computer-docking simulation, apigenin interacted with the same mode of cocrystallized alpha-naphthoflavone in the active site of CYP1A2, and then the B ring of apigenin was placed close to the heme iron of the enzyme with a single orientation. alpha-naphthoflavone cytochrome P450 family 1 subfamily A member 2 Homo sapiens