Title : Tyr1 and Ile7 of glucose-dependent insulinotropic polypeptide (GIP) confer differential ligand selectivity toward GIP and glucagon-like peptide-1 receptors.

Pub. Date : 2010 Aug

PMID : 20799012






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 A mutated GIP peptide in which Tyr(1), Ile(7), Asp(15), and His(18) were replaced by His, Thr, Glu, and Ala, respectively, was able to activate both GLP1R and GIPR with moderate potency. Alanine gastric inhibitory polypeptide Homo sapiens