Title : Inhibition of phosphatidylinositol 3-kinase promotes tumor cell resistance to chemotherapeutic agents via a mechanism involving delay in cell cycle progression.

Pub. Date : 2010 Nov 15

PMID : 20736003






1 Functional Relationships(s)
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1 Inhibition of PI3K signaling also resulted in higher levels of the cyclin-dependent kinase inhibitors p21(Waf1/Cip1) and p27(Kip1); and knockdown of p27(kip1) with siRNA attenuated resistance to doxorubicin in cells treated with LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one cyclin dependent kinase inhibitor 1B Homo sapiens