Pub. Date : 2010 Sep
PMID : 20718739
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND AND PURPOSE: Long-term morphine treatment enhances pain neurotransmitter [such as calcitonin gene-related peptide (CGRP)] levels in the spinal cord. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 2 | BACKGROUND AND PURPOSE: Long-term morphine treatment enhances pain neurotransmitter [such as calcitonin gene-related peptide (CGRP)] levels in the spinal cord. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 3 | It has been suggested previously that increased spinal CGRP may contribute to sustained morphine-mediated paradoxical pain sensitization and antinociceptive tolerance. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 4 | Previous in vitro studies from our group indicated that Raf-1 kinase-mediated adenylyl cyclase superactivation played a crucial role in sustained morphine-mediated augmentation of basal and evoked CGRP release from cultured primary sensory neurons. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 5 | KEY RESULTS: Selective knockdown of spinal Raf-1 protein levels by i.th Raf-1-selective siRNA pretreatment significantly attenuated sustained morphine-mediated up-regulation of CGRP immunoreactivity in the spinal cord of rats and prevented the development of thermal hyperalgesia, mechanical allodynia and antinociceptive tolerance. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |