Pub. Date : 2010 Oct
PMID : 20717005
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celecoxib inhibits cell proliferation through the activation of ERK and p38 MAPK in head and neck squamous cell carcinoma cell lines. | Celecoxib | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Celecoxib inhibits cell proliferation through the activation of ERK and p38 MAPK in head and neck squamous cell carcinoma cell lines. | Celecoxib | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | We assessed the effect of celecoxib on extracellular signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase activity by a transcription factor activation assay then evaluated, if these factors might be involved in the COX-2-independent tumor-killing effect of celecoxib by blocking their activity. | Celecoxib | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | We assessed the effect of celecoxib on extracellular signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase activity by a transcription factor activation assay then evaluated, if these factors might be involved in the COX-2-independent tumor-killing effect of celecoxib by blocking their activity. | Celecoxib | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | We assessed the effect of celecoxib on extracellular signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase activity by a transcription factor activation assay then evaluated, if these factors might be involved in the COX-2-independent tumor-killing effect of celecoxib by blocking their activity. | Celecoxib | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | We found that the blocking activation of ERK and/or p38 could reverse the celecoxib-induced cell growth inhibition by 50-80% in HNSCC cell lines, but it was not tested in cancer cells of other types. | Celecoxib | mitogen-activated protein kinase 1 | Homo sapiens |
| 7 | We found that the blocking activation of ERK and/or p38 could reverse the celecoxib-induced cell growth inhibition by 50-80% in HNSCC cell lines, but it was not tested in cancer cells of other types. | Celecoxib | mitogen-activated protein kinase 1 | Homo sapiens |
| 8 | In conclusion, our study suggests that most COX-2-independent tumor-killing action of celecoxib is mediated by the upregulation of ERK and/or p38 activity in HNSCC cells. | Celecoxib | mitogen-activated protein kinase 1 | Homo sapiens |
| 9 | In conclusion, our study suggests that most COX-2-independent tumor-killing action of celecoxib is mediated by the upregulation of ERK and/or p38 activity in HNSCC cells. | Celecoxib | mitogen-activated protein kinase 1 | Homo sapiens |