Title : Splice variants of SmgGDS control small GTPase prenylation and membrane localization.

Pub. Date : 2010 Nov 12

PMID : 20709748






1 Functional Relationships(s)
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1 We demonstrate that insertion of the dominant negative mutation to inhibit GDP/GTP exchange diminishes prenylation of Rap1A and RhoA, enhances prenylation of Rac1, and does not detectably alter prenylation of K-Ras. Guanosine Diphosphate RAP1A, member of RAS oncogene family Homo sapiens