Title : Human variation in CYP-specific chlorpyrifos metabolism.

Pub. Date : 2010 Oct 29

PMID : 20709133






2 Functional Relationships(s)
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1 Chlorpyrifos metabolism by individual human liver microsomes was significantly correlated with CYP2B6, CYP2C19 and CYP3A4 related activity. Chlorpyrifos cytochrome P450 family 2 subfamily C member 19 Homo sapiens
2 Calculations of percent total normalized rates (% TNR) and the chemical inhibitors ketoconazole and ticlopidine were used to confirm the importance of CYP2B6, CYP2C19, and CYP3A4 for the metabolism of chlorpyrifos. Chlorpyrifos cytochrome P450 family 2 subfamily C member 19 Homo sapiens