Title : Activation of PDE2 and PDE5 by specific GAF ligands: delayed activation of PDE5.

Pub. Date : 2010 Dec

PMID : 20698857






2 Functional Relationships(s)
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1 The ligand for the GAF domains of PDE5, 8-Br-cGMP, elicited a 20-fold GAF-dependent activation and moreover revealed a time-dependent increase in PDE5 activity that occurred independently of a GAF ligand. 8-bromoguanosino-3',5'-cyclic monophosphorothioate phosphodiesterase 5A Homo sapiens
2 The ligand for the GAF domains of PDE5, 8-Br-cGMP, elicited a 20-fold GAF-dependent activation and moreover revealed a time-dependent increase in PDE5 activity that occurred independently of a GAF ligand. 8-bromoguanosino-3',5'-cyclic monophosphorothioate phosphodiesterase 5A Homo sapiens