Pub. Date : 2010 Nov 1
PMID : 20696143
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol modulates angiogenesis through the GSK3beta/beta-catenin/TCF-dependent pathway in human endothelial cells. | Resveratrol | glycogen synthase kinase 3 beta | Homo sapiens |
| 2 | Correspondingly, GSK3beta, a negative regulator of beta-catenin, turned into a less active state (phosphorylated at Ser9) in cells exposed to 5muM of resveratrol, but became more active at 20muM. | Resveratrol | glycogen synthase kinase 3 beta | Homo sapiens |
| 3 | We demonstrated that both Akt and ERK signaling pathways, which are known to be critical for angiogenesis, became activated in response to 5muM of resveratrol and functioned to inactivate GSK3beta. | Resveratrol | glycogen synthase kinase 3 beta | Homo sapiens |