Pub. Date : 2010
PMID : 20693797
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Our study was designed to evaluate the impact of EGFR stimulation on cisplatin-induced DNA damage. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
2 | Twenty-four-hour stimulation of tissue cultures with transforming growth factor alpha (TGF-alpha), a specific EGFR ligand, resulted in a reduction of cisplatin-induced DNA damage by 35% in cases, whereas in controls TGF-alpha had no effect. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
3 | This reflects a statistically significant increase in cellular chemoresistance to cisplatin following TGF-alpha stimulation and helps to further understand effects of EGFR antisense therapy in combination with chemotherapy. | Cisplatin | epidermal growth factor receptor | Homo sapiens |