Title : Transforming growth factor alpha stimulation of mucosal tissue cultures from head and neck squamous cell carcinoma patients increases chemoresistance to cisplatin.

Pub. Date : 2010

PMID : 20693797






3 Functional Relationships(s)
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1 Our study was designed to evaluate the impact of EGFR stimulation on cisplatin-induced DNA damage. Cisplatin epidermal growth factor receptor Homo sapiens
2 Twenty-four-hour stimulation of tissue cultures with transforming growth factor alpha (TGF-alpha), a specific EGFR ligand, resulted in a reduction of cisplatin-induced DNA damage by 35% in cases, whereas in controls TGF-alpha had no effect. Cisplatin epidermal growth factor receptor Homo sapiens
3 This reflects a statistically significant increase in cellular chemoresistance to cisplatin following TGF-alpha stimulation and helps to further understand effects of EGFR antisense therapy in combination with chemotherapy. Cisplatin epidermal growth factor receptor Homo sapiens