Title : Dual inhibition of both the epidermal growth factor receptor and erbB2 effectively inhibits the promotion of skin tumors during two-stage carcinogenesis.

Pub. Date : 2010 Aug

PMID : 20682802






2 Functional Relationships(s)
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1 GW2974 effectively inhibited skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in wild-type and BK5.erbB2 mice, although a more marked effect was seen in BK5.erbB2 mice. Tetradecanoylphorbol Acetate erb-b2 receptor tyrosine kinase 2 Mus musculus
2 GW2974 inhibited 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperproliferation, which correlated with reduced activation of both the EGFR and erbB2. Tetradecanoylphorbol Acetate erb-b2 receptor tyrosine kinase 2 Mus musculus