Title : Flexible regions within I{kappa}B{alpha} create the ubiquitin-independent degradation signal.

Pub. Date : 2010 Oct 22

PMID : 20682784






3 Functional Relationships(s)
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1 We previously showed that the ubiquitin-independent degradation signal of unbound IkappaBalpha was located in the C-terminal PEST region, and we have now identified a single tyrosine, Tyr-289, and determined that the hydrophobic character of the tyrosine is important for the rapid turnover of IkappaBalpha. Tyrosine NFKB inhibitor alpha Homo sapiens
2 We previously showed that the ubiquitin-independent degradation signal of unbound IkappaBalpha was located in the C-terminal PEST region, and we have now identified a single tyrosine, Tyr-289, and determined that the hydrophobic character of the tyrosine is important for the rapid turnover of IkappaBalpha. Tyrosine NFKB inhibitor alpha Homo sapiens
3 We previously showed that the ubiquitin-independent degradation signal of unbound IkappaBalpha was located in the C-terminal PEST region, and we have now identified a single tyrosine, Tyr-289, and determined that the hydrophobic character of the tyrosine is important for the rapid turnover of IkappaBalpha. Tyrosine NFKB inhibitor alpha Homo sapiens