Pub. Date : 2010 Oct 15
PMID : 20668093
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic treatment of R6/2 mice with an agonist of PPARgamma (thiazolidinedione, TZD) rescued progressive weight loss, motor deterioration, formation of mutant Htt aggregates, jeopardized global ubiquitination profiles, reduced expression of two neuroprotective proteins (brain-derived neurotrophic factor and Bcl-2) and shortened life span exhibited by these mice. | tzd | peroxisome proliferator activated receptor gamma | Mus musculus |
| 2 | By reducing HTT aggregates and, thus, ameliorating the recruitment of PPARgamma into HTT aggregates, chronic TZD treatment also elevated the availability of the PPARgamma protein and subsequently normalized the expression of two of its downstream genes (the glucose transporter type 4 and PPARgamma coactivator-1 alpha genes). | tzd | peroxisome proliferator activated receptor gamma | Mus musculus |
| 3 | By reducing HTT aggregates and, thus, ameliorating the recruitment of PPARgamma into HTT aggregates, chronic TZD treatment also elevated the availability of the PPARgamma protein and subsequently normalized the expression of two of its downstream genes (the glucose transporter type 4 and PPARgamma coactivator-1 alpha genes). | tzd | peroxisome proliferator activated receptor gamma | Mus musculus |
| 4 | The protective effects described above appear to have been exerted, at least partially, via direct activation of PPARgamma in the brain, as TZD was detected in the brains of mice treated with TZD and because a PPARgamma agonist (rosiglitazone) protected striatal cells from mHTT-evoked energy deficiency and toxicity. | tzd | peroxisome proliferator activated receptor gamma | Mus musculus |
| 5 | The protective effects described above appear to have been exerted, at least partially, via direct activation of PPARgamma in the brain, as TZD was detected in the brains of mice treated with TZD and because a PPARgamma agonist (rosiglitazone) protected striatal cells from mHTT-evoked energy deficiency and toxicity. | tzd | peroxisome proliferator activated receptor gamma | Mus musculus |
| 6 | The protective effects described above appear to have been exerted, at least partially, via direct activation of PPARgamma in the brain, as TZD was detected in the brains of mice treated with TZD and because a PPARgamma agonist (rosiglitazone) protected striatal cells from mHTT-evoked energy deficiency and toxicity. | tzd | peroxisome proliferator activated receptor gamma | Mus musculus |