Title : Decoupling of receptor and downstream signals in the Akt pathway by its low-pass filter characteristics.

Pub. Date : 2010 Jul 27

PMID : 20664065






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1 Furthermore, we found that lapatinib, an EGFR inhibitor used as an anticancer drug, converted strong, transient Akt phosphorylation into weak, sustained Akt phosphorylation, and, because of the low-pass filter characteristics of the Akt pathway, this led to stronger S6 phosphorylation than occurred in the absence of the inhibitor. Lapatinib epidermal growth factor receptor Rattus norvegicus