Title : Correlations between polyamine analogue-induced increases in spermidine/spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines.

Pub. Date : 1991 Jul 15

PMID : 2065327






4 Functional Relationships(s)
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1 Correlations between polyamine analogue-induced increases in spermidine/spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines. Polyamines spermidine/spermine N1-acetyltransferase 1 Homo sapiens
2 In MALME-3 cells, SSAT accumulation was found to be differentially modulated by the BESPM homologues, N1,N11-bis-(ethyl)norspermine and N1,N14-bis-(ethyl)homospermine, which were 5-fold more and 9-fold less effective, respectively, than BESPM in increasing SSAT but similar in analogue uptake and effects on polyamine biosynthesis and cell growth inhibition. Polyamines spermidine/spermine N1-acetyltransferase 1 Homo sapiens
3 The relationship between SSAT induction and growth sensitivity was deduced to be a possible function of increased excretion of acetylated polyamines leading to enhanced polyamine pool depletion. Polyamines spermidine/spermine N1-acetyltransferase 1 Homo sapiens
4 The relationship between SSAT induction and growth sensitivity was deduced to be a possible function of increased excretion of acetylated polyamines leading to enhanced polyamine pool depletion. Polyamines spermidine/spermine N1-acetyltransferase 1 Homo sapiens