Title : p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase.

Pub. Date : 2010 Aug

PMID : 20647331






2 Functional Relationships(s)
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1 The importance of the p53 pathway to PIM1-driven cellular senescence was further shown by the observation that expression of dominant-negative p53 or shRNA targeting p21 blocked the PIM1-induced changes in the DNA damage response and increases in SA-beta-Gal activity. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens
2 The importance of the p53 pathway to PIM1-driven cellular senescence was further shown by the observation that expression of dominant-negative p53 or shRNA targeting p21 blocked the PIM1-induced changes in the DNA damage response and increases in SA-beta-Gal activity. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens