Title : Substrate and product analogues as human O-GlcNAc transferase inhibitors.

Pub. Date : 2011 Mar

PMID : 20640461






1 Functional Relationships(s)
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1 Here, we describe the synthesis of novel UDP-GlcNAc/UDP analogues and evaluate their inhibitory properties and structural binding modes in vitro alongside alloxan, a previously reported weak OGT inhibitor. Alloxan O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens