Title : Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b.

Pub. Date : 2010 Aug

PMID : 20639876






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Syk interacted with and induced tyrosine phosphorylation of MyD88 and TRIF, which led to degradation of these adaptor molecules by the E3 ubiquitin ligase Cbl-b. Tyrosine spleen tyrosine kinase Mus musculus