Title : The multikinase inhibitor sorafenib reverses the suppression of IL-12 and enhancement of IL-10 by PGE₂ in murine macrophages.

Pub. Date : 2010 Oct

PMID : 20637838






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 Sorafenib inhibited the activation of the MAP kinase p38 and its downstream target mitogen and stress activated protein kinase (MSK), and partially inhibited protein kinase B (AKT) and its subsequent inactivation of the downstream target glycogen synthase kinase 3-beta (GSK3-beta). Sorafenib glycogen synthase kinase 3 beta Mus musculus
2 Sorafenib inhibited the activation of the MAP kinase p38 and its downstream target mitogen and stress activated protein kinase (MSK), and partially inhibited protein kinase B (AKT) and its subsequent inactivation of the downstream target glycogen synthase kinase 3-beta (GSK3-beta). Sorafenib glycogen synthase kinase 3 beta Mus musculus