Title : Methyl 2-cyano-3,11-dioxo-18-olean-1,12-dien-30-oate (CDODA-Me), a derivative of glycyrrhetinic acid, functions as a potent angiogenesis inhibitor.

Pub. Date : 2010 Oct

PMID : 20631299






3 Functional Relationships(s)
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1 Our results showed that CDODA-Me significantly suppressed the activation of VEGF receptor 2 (VEGFR2) and interfered with the mammalian target of rapamycin (mTOR) signaling, including mTOR kinase and its downstream ribosomal S6 kinase (S6K), but had little effect on the activities of extracellular signal-regulated protein kinase and AKT. methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate kinase insert domain receptor Homo sapiens
2 Our results showed that CDODA-Me significantly suppressed the activation of VEGF receptor 2 (VEGFR2) and interfered with the mammalian target of rapamycin (mTOR) signaling, including mTOR kinase and its downstream ribosomal S6 kinase (S6K), but had little effect on the activities of extracellular signal-regulated protein kinase and AKT. methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate kinase insert domain receptor Homo sapiens
3 Taken together, CDODA-Me blocks several key steps of angiogenesis by inhibiting VEGF/VEGFR2 and mTOR/S6K signaling pathways, making the compound a promising agent for the treatment of cancer and angiogenesis-related pathologies. methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate kinase insert domain receptor Homo sapiens