Title : The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: a structural analysis of the binding interactions of Gleevec, Nexavar, and BIRB-796.

Pub. Date : 2010 Aug 1

PMID : 20621496






1 Functional Relationships(s)
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1 Here, we present a structural comparison of the important and similar interactions necessary for Gleevec(R), Nexavar, and BIRB-796 to bind to their respective DFG-out allosteric binding pockets and the selectivity of each with respect to c-Abl, B-Raf, and p38alpha. Sorafenib B-Raf proto-oncogene, serine/threonine kinase Homo sapiens