Title : Diabetes depresses synaptic transmission in sympathetic ganglia by inactivating nAChRs through a conserved intracellular cysteine residue.

Pub. Date : 2010 Jun 24

PMID : 20620869






1 Functional Relationships(s)
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1 To test this idea, we investigated cultured sympathetic neurons and show that hyperglycemia inactivates nAChRs through a mechanism involving an elevation in reactive oxygen species and an interaction with highly conserved cysteine residues located near the intracellular mouth of the nAChR channel. Cysteine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus