Title : Design, synthesis and antifungal activity of isosteric analogues of benzoheterocyclic N-myristoyltransferase inhibitors.

Pub. Date : 2010 Sep

PMID : 20615585






2 Functional Relationships(s)
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1 A series of benzoxazole and indole derivatives were designed and synthesized as isosteric analogues of benzoheterocyclic NMT Inhibitors. Benzoxazoles N-myristoyltransferase 1 Homo sapiens
2 The antifungal activity of benzoxazole derivative 8f was comparable or superior to that of fluconazole, which can serve as a good starting point for further studies of structural diversity of the benzoheterocyclic NMT inhibitors. Benzoxazoles N-myristoyltransferase 1 Homo sapiens