| Protein Name | N-myristoyltransferase 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 4836 |
| Gene Symbol | NMT1 |
| UniProt | P30419 (NMT1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
185
Total Number of Articles : 130 |
Description |
N-myristoyltransferase 1 |
| Gene Summary |
Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008] |
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| Properties | |