Protein Name N-myristoyltransferase 1
Organism Homo sapiens
Gene ID 4836
Gene Symbol


UniProt P30419 (NMT1_HUMAN)
Relationships Total Number of functionally related compound(s) : 185
Total Number of Articles : 130

N-myristoyltransferase 1

Gene Summary

Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]

  • glycylpeptide N-tetradecanoyltransferase 1
  • alternative, short form NMT-S
  • long form, NMT-L
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