Pub. Date : 2010
PMID : 20610887
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stereoselective transport of methotrexate (L-amethopterin, L-MTX) and its antipode (D-amethopterin, D-MTX) by the proton-coupled folate transporter (PCFT) was examined using PCFT-expressing HEK293 cells (PCFT-HEK293 cells). | lometrexol | solute carrier family 46 member 1 | Homo sapiens |
| 2 | Stereoselective transport of methotrexate (L-amethopterin, L-MTX) and its antipode (D-amethopterin, D-MTX) by the proton-coupled folate transporter (PCFT) was examined using PCFT-expressing HEK293 cells (PCFT-HEK293 cells). | lometrexol | solute carrier family 46 member 1 | Homo sapiens |
| 3 | Stereoselective transport of methotrexate (L-amethopterin, L-MTX) and its antipode (D-amethopterin, D-MTX) by the proton-coupled folate transporter (PCFT) was examined using PCFT-expressing HEK293 cells (PCFT-HEK293 cells). | lometrexol | solute carrier family 46 member 1 | Homo sapiens |
| 4 | Stereoselective transport of methotrexate (L-amethopterin, L-MTX) and its antipode (D-amethopterin, D-MTX) by the proton-coupled folate transporter (PCFT) was examined using PCFT-expressing HEK293 cells (PCFT-HEK293 cells). | lometrexol | solute carrier family 46 member 1 | Homo sapiens |
| 5 | The initial uptake rate of L-MTX into PCFT-HEK293 cells followed Michaelis-Menten kinetics with a K(m) value of approximately 5.0 microM. | lometrexol | solute carrier family 46 member 1 | Homo sapiens |
| 6 | The present study revealed that the transport of MTX enantiomers by PCFT is highly stereoselective with the uptake clearance of L-MTX being approximately 40-fold greater than that of D-MTX. | lometrexol | solute carrier family 46 member 1 | Homo sapiens |