Title : Inhibition of human liver microsomal CYP by nateglinide.

Pub. Date : 2010 May

PMID : 20609060






1 Functional Relationships(s)
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1 METHODS: We used typical substrates (7-ethoxyresorufin for CYP1A1/2, tolbutamide for CYP2C9, S-mephenytoin for CYP2C19, bufuralol for CYP2D6, chlorzoxazone for CYP2E1 and midazolam for CYP3A4) in the evaluation of the inhibitory effects, and examined the possibility of mechanism-based inhibition (MBI) by evaluating the influence of pre-incubation in the inhibition. Tolbutamide cytochrome P450 family 2 subfamily C member 9 Homo sapiens