Pub. Date : 2011 Apr
PMID : 20599230
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dual actions of cilnidipine in human internal thoracic artery: inhibition of calcium channels and enhancement of endothelial nitric oxide synthase. | cilnidipine | nitric oxide synthase 3 | Homo sapiens |
| 2 | Cilnidipine increased the expression of endothelial nitric oxide synthase mRNA by 42.4% (P < .05) and enhanced phosphorylation level of endothelial nitric oxide synthase at Ser(1177) by 37.0% (P < .05). | cilnidipine | nitric oxide synthase 3 | Homo sapiens |
| 3 | Cilnidipine increased the expression of endothelial nitric oxide synthase mRNA by 42.4% (P < .05) and enhanced phosphorylation level of endothelial nitric oxide synthase at Ser(1177) by 37.0% (P < .05). | cilnidipine | nitric oxide synthase 3 | Homo sapiens |
| 4 | CONCLUSIONS: The new generation of calcium channel antagonist cilnidipine relaxes human arteries through calcium channel antagonism and increases production of nitric oxide by enhancement of endothelial nitric oxide synthase. | cilnidipine | nitric oxide synthase 3 | Homo sapiens |