Title : Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy.

Pub. Date : 2010 Jul 30

PMID : 20595043






1 Functional Relationships(s)
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1 The work also describes the results of docking synthetic inhibitors, including the drug abiraterone and the natural substrate pregnenolone, in the CYP17 active site together with molecular dynamics simulations on the complexes. Pregnenolone cytochrome P450 family 17 subfamily A member 1 Homo sapiens