Pub. Date : 2011 Feb 1
PMID : 20586612
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Null of SOD1 and GPX1 elevated respective islet superoxide and hydroperoxide production, and upregulated p53 phosphorylation. | Superoxides | superoxide dismutase 1, soluble | Mus musculus |
| 2 | Knockout of SOD1 downregulated the foxhead box A2/pancreatic and duodenal homeobox 1 pathway in a superoxide-dependent fashion at epigenetic, mRNA, and protein levels in islets, but improved insulin signaling in liver and muscle. | Superoxides | superoxide dismutase 1, soluble | Mus musculus |