Title : Targeting ADAM-17/notch signaling abrogates the development of systemic sclerosis in a murine model.

Pub. Date : 2010 Nov

PMID : 20583103






1 Functional Relationships(s)
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Protein Name
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1 In HOCl-injected mice, DAPT significantly reduced the development of skin and lung fibrosis, decreased skin fibroblast proliferation and ex vivo serum-induced endothelial H(2)O(2) production, and abrogated the production of anti-DNA topoisomerase I antibodies. dapt topoisomerase (DNA) I Mus musculus