Pub. Date : 2011 Feb
PMID : 20573493
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Docosahexaenoic acid attenuates VCAM-1 expression and NF-kappaB activation in TNF-alpha-treated human aortic endothelial cells. | Docosahexaenoic Acids | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | In line with NF-kappaB signaling pathway, DHA suppressed the TNF-alpha-activated IkappaBalpha phosphorylation and degradation as well as IkappaB kinase-beta phosphorylation. | Docosahexaenoic Acids | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Subsequently, translocation of the NF-kappaB (p50/p65) and AP-1 (c-Fos/c-Jun) subunits was down-regulated by DHA in the nucleus of HAECs. | Docosahexaenoic Acids | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Subsequently, translocation of the NF-kappaB (p50/p65) and AP-1 (c-Fos/c-Jun) subunits was down-regulated by DHA in the nucleus of HAECs. | Docosahexaenoic Acids | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | These results suggest that DHA negatively regulates TNF-alpha-induced VCAM-1 expression through attenuation of NF-kappaB signaling pathway and AP-1 activation. | Docosahexaenoic Acids | nuclear factor kappa B subunit 1 | Homo sapiens |