Title : Combining the FLT3 inhibitor PKC412 and the triterpenoid CDDO-Me synergistically induces apoptosis in acute myeloid leukemia with the internal tandem duplication mutation.

Pub. Date : 2010 Jul

PMID : 20571062






1 Functional Relationships(s)
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1 Here, we report that CDDO-Me blocks targeting of NFkappaB to the nucleus by inhibiting IkappaB kinase beta-mediated phosphorylation of IkappaBalpha. bardoxolone methyl nuclear factor kappa B subunit 1 Homo sapiens