Pub. Date : 2010 Sep
PMID : 20570635
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity. | Oxysterols | ATP binding cassette subfamily G member 1 | Homo sapiens |
| 2 | Trophoblasts transfected with ABCA1 or ABCG1 siRNA were more sensitive to toxic oxysterols substrates (25-hydroxycholesterol and 7-ketocholesterol) compared to mock-transfected cells, while prior treatment with T0901317 reduced oxysterol-mediated toxicity. | Oxysterols | ATP binding cassette subfamily G member 1 | Homo sapiens |
| 3 | Trophoblasts transfected with ABCA1 or ABCG1 siRNA were more sensitive to toxic oxysterols substrates (25-hydroxycholesterol and 7-ketocholesterol) compared to mock-transfected cells, while prior treatment with T0901317 reduced oxysterol-mediated toxicity. | Oxysterols | ATP binding cassette subfamily G member 1 | Homo sapiens |
| 4 | These results identify syncytial ABCA1 and ABCG1 as important, inducible cholesterol transporters which also prevent placental accumulation of cytotoxic oxysterols. | Oxysterols | ATP binding cassette subfamily G member 1 | Homo sapiens |