Pub. Date : 1991 Jul
PMID : 2056586
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of prostatic tumor cell proliferation by suramin: alterations in TGF alpha-mediated autocrine growth regulation and cell cycle distribution. | Suramin | transforming growth factor alpha | Homo sapiens |
| 2 | The present studies were designed to evaluate the ability of suramin to inhibit PC3 and DU145 proliferation by interfering with TGFa-mediated autocrine growth. | Suramin | transforming growth factor alpha | Homo sapiens |
| 3 | Suramin also interfered with TGFa-mediated growth mechanisms. | Suramin | transforming growth factor alpha | Homo sapiens |
| 4 | Specifically, suramin reduced the specific binding of TGFa to PC3 and DU145 cells. | Suramin | transforming growth factor alpha | Homo sapiens |
| 5 | Additionally, the inhibitory effect of suramin on DU145 was reversed by cultivation of cells in the presence of excess TGFa. | Suramin | transforming growth factor alpha | Homo sapiens |
| 6 | These studies show that the inhibitory effect of suramin on PC3 and DU145 cell growth is mediated, in part, by alteration of TGFa-mediated autocrine growth mechanisms and cell cycle kinetics. | Suramin | transforming growth factor alpha | Homo sapiens |