Title : Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: potential regulation by targeting rho proteins.

Pub. Date : 2010 Aug 19

PMID : 20562912






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Lovastatin-induced rhoA was inactive as EGF stimulation failed to activate rhoA and inhibition of the rho-associated kinase, a target and mediator of rhoA function, with Y-27632 also showed inhibitory effects on EGFR dimerization. Y 27632 epidermal growth factor receptor Homo sapiens