Pub. Date : 2010 Jun 29
PMID : 20547845
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release. | Cysteine | high mobility group box 1 | Homo sapiens |
| 2 | Surface plasmon resonance studies indicate that HMGB1 binds specifically to TLR4, and that this binding requires a cysteine in position 106. | Cysteine | high mobility group box 1 | Homo sapiens |
| 3 | Inhibition of TLR4 binding with neutralizing anti-HMGB1 mAb or by mutating cysteine 106 prevents HMGB1 activation of cytokine release. | Cysteine | high mobility group box 1 | Homo sapiens |