Pub. Date : 2010 Jun 8
PMID : 20544024
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS AND FINDINGS: We have determined, by X-ray crystallography, the first reported structure of TbCatB in complex with the cathepsin B selective inhibitor CA074. | N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline | cathepsin B | Homo sapiens |
| 2 | The TbCat*CA074 structure confirms that the occluding loop, which is an essential part of the substrate-binding site, creates a larger prime side pocket in the active site cleft than is found in mammalian cathepsin B-small molecule structures. | N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline | cathepsin B | Homo sapiens |