Title : Cyclin E deregulation impairs mitotic progression through premature activation of Cdc25C.

Pub. Date : 2010 Jun 15

PMID : 20530684






1 Functional Relationships(s)
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1 Specifically, the cyclin E/CDK2 complex phosphorylates Cdc25C on Ser(214), leading to its premature activation, which coincides with higher cyclin B/CDK1 and Polo-like kinase 1 (PLK1) activities in an S-phase-enriched population that result in faster mitotic entry. Serine cyclin dependent kinase 2 Homo sapiens