Title : Tryptophan/kynurenine metabolism in human leukocytes is independent of superoxide and is fully maintained in chronic granulomatous disease.

Pub. Date : 2010 Sep 9

PMID : 20511543






2 Functional Relationships(s)
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1 Based on recent mouse studies, the lack of O(2)( )-dependent interferon gamma (IFNgamma)-induced synthesis of kynurenine (kyn), an anti-inflammatory tryptophan metabolite produced by indolamine 2,3 deoxygenase (IDO), was proposed as a cause of hyperinflammation in CGD and this pathway has been considered for clinical intervention. Kynurenine interferon gamma Mus musculus
2 Based on recent mouse studies, the lack of O(2)( )-dependent interferon gamma (IFNgamma)-induced synthesis of kynurenine (kyn), an anti-inflammatory tryptophan metabolite produced by indolamine 2,3 deoxygenase (IDO), was proposed as a cause of hyperinflammation in CGD and this pathway has been considered for clinical intervention. Kynurenine interferon gamma Mus musculus