PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20511543-2 2010 Based on recent mouse studies, the lack of O(2)( )-dependent interferon gamma (IFNgamma)-induced synthesis of kynurenine (kyn), an anti-inflammatory tryptophan metabolite produced by indolamine 2,3 deoxygenase (IDO), was proposed as a cause of hyperinflammation in CGD and this pathway has been considered for clinical intervention. Kynurenine 110-120 interferon gamma Mus musculus 61-77 20511543-2 2010 Based on recent mouse studies, the lack of O(2)( )-dependent interferon gamma (IFNgamma)-induced synthesis of kynurenine (kyn), an anti-inflammatory tryptophan metabolite produced by indolamine 2,3 deoxygenase (IDO), was proposed as a cause of hyperinflammation in CGD and this pathway has been considered for clinical intervention. Kynurenine 110-120 interferon gamma Mus musculus 79-87