Title : Comprehensive characterization of a novel intronic pseudo-exon inserted within an e14/a2 BCR-ABL rearrangement in a patient with chronic myeloid leukemia.

Pub. Date : 2010 Jul

PMID : 20508029






1 Functional Relationships(s)
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1 Using a PCR-based method, this analysis revealed that i) BCR intron 14 brought a potential lariat branch point and the polypyrimidine tract, ii) the BCR-ABL breakpoint created a chimeric acceptor site, and iii) the inserted sequence of ABL intron Ib carried at its 3" end a well-conserved donor splice site. polypyrimidine BCR activator of RhoGEF and GTPase Homo sapiens