Pub. Date : 2010 May 27
PMID : 20504373
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vaticanol C, a resveratrol tetramer, activates PPARalpha and PPARbeta/delta in vitro and in vivo. | vaticanol C | peroxisome proliferator activated receptor alpha | Mus musculus |
| 2 | RESULTS: We show that vaticanol C activates PPARalpha and PPARbeta/delta in cell-based reporter assays, but does not activate SIRT1. | vaticanol C | peroxisome proliferator activated receptor alpha | Mus musculus |
| 3 | Eight-week intake of vaticanol C with a high fat diet upregulates hepatic expression of PPARalpha-responsive genes such as cyp4a10, cyp4a14 and FABP1, and skeletal muscle expression of PPARbeta/delta-responsive genes, such as UCP3 and PDK4 (pyruvate dehydrogenase kinase, isoform 4), in wild-type, but not PPARalpha-knockout mice. | vaticanol C | peroxisome proliferator activated receptor alpha | Mus musculus |
| 4 | Eight-week intake of vaticanol C with a high fat diet upregulates hepatic expression of PPARalpha-responsive genes such as cyp4a10, cyp4a14 and FABP1, and skeletal muscle expression of PPARbeta/delta-responsive genes, such as UCP3 and PDK4 (pyruvate dehydrogenase kinase, isoform 4), in wild-type, but not PPARalpha-knockout mice. | vaticanol C | peroxisome proliferator activated receptor alpha | Mus musculus |
| 5 | CONCLUSION: Vaticanol C, a resveratrol tetramer, activated PPARalpha and PPARbeta/delta in vitro and in vivo. | vaticanol C | peroxisome proliferator activated receptor alpha | Mus musculus |
| 6 | These findings indicate that activation of PPARalpha and PPARbeta/delta by vaticanol C may be a novel mechanism, affording beneficial effects against lifestyle-related diseases. | vaticanol C | peroxisome proliferator activated receptor alpha | Mus musculus |