Pub. Date : 2010
PMID : 20500834
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats. | pristane | toll-like receptor 3 | Rattus norvegicus |
| 2 | RESULTS: By screening the TLR expression profile in spleen of DA rats after pristane injection, we found that TLR3 was the most early and prominently upregulated TLR. | pristane | toll-like receptor 3 | Rattus norvegicus |
| 3 | Both TLR3 mRNA and protein expression of spleen were upregulated at 6 and 26 days after pristane injection. | pristane | toll-like receptor 3 | Rattus norvegicus |
| 4 | Particularly, TLR3 expression was induced in splenic macrophages of PIA rats, and also in the NR8383 cell line after pristane stimulation in a dose- and time- dependent manner. | pristane | toll-like receptor 3 | Rattus norvegicus |
| 5 | Upregulation of interferon beta (IFN-beta) and TNF-alpha by pristane stimulation was blocked by anti-TLR3 antibody in NR8383. | pristane | toll-like receptor 3 | Rattus norvegicus |