Title : cAMP mediators of pulsatile insulin secretion from glucose-stimulated single beta-cells.

Pub. Date : 2010 Jul 23

PMID : 20498366






2 Functional Relationships(s)
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1 However, the amplitude of the PIP(3) response after PKA inhibition was restored by a specific agonist to the cAMP-dependent guanine nucleotide exchange factor Epac. pip(3) Rap guanine nucleotide exchange factor (GEF) 3 Mus musculus
2 Suppression of cAMP formation with adenylyl cyclase inhibitors reduced already established PIP(3) oscillations in glucose-stimulated cells, and this effect was almost completely counteracted by the Epac agonist. pip(3) Rap guanine nucleotide exchange factor (GEF) 3 Mus musculus