Protein Name Rap guanine nucleotide exchange factor (GEF) 3
Organism Mus musculus
Gene ID 223864
Gene Symbol

Rapgef3

UniProt Q8VCC8 (RPGF3_MOUSE), Q3UQC2 (Q3UQC2_MOUSE), E9Q2E5 (E9Q2E5_MOUSE), Q3TES7 (Q3TES7_MOUSE)
Relationships Total Number of functionally related compound(s) : 135
Total Number of Articles : 212
Description

Rap guanine nucleotide exchange factor (GEF) 3

Gene Summary

Enables guanyl-nucleotide exchange factor activity. Involved in associative learning. Predicted to be located in several cellular components, including basolateral part of cell; brush border membrane; and distal axon. Predicted to be active in plasma membrane. Is expressed in brain; heart; lens; lung; and metanephros. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human RAPGEF3 (Rap guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • rap guanine nucleotide exchange factor 3
  • Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
  • cAMP-GEFI
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Properties