Title : Chronic administration of sildenafil modified the impaired VEGF system and improved the erectile function in rats with diabetic erectile dysfunction.

Pub. Date : 2010 Dec

PMID : 20487237






5 Functional Relationships(s)
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1 Chronic administration of sildenafil modified the impaired VEGF system and improved the erectile function in rats with diabetic erectile dysfunction. Sildenafil Citrate vascular endothelial growth factor A Rattus norvegicus
2 AIM: To determine whether chronic sildenafil administration can modify the impaired vascular endothelial growth factor (VEGF) system and improve the erectile function in rats with diabetic erectile dysfunction. Sildenafil Citrate vascular endothelial growth factor A Rattus norvegicus
3 AIM: To determine whether chronic sildenafil administration can modify the impaired vascular endothelial growth factor (VEGF) system and improve the erectile function in rats with diabetic erectile dysfunction. Sildenafil Citrate vascular endothelial growth factor A Rattus norvegicus
4 CONCLUSION: We demonstrated that daily sildenafil administration can restore the impaired VEGF system in the penis of DMED rats and progressively improve both erectile function and endothelial function, suggesting a potential general mechanism of improved signaling through the VEGF/eNOS signaling cascade. Sildenafil Citrate vascular endothelial growth factor A Rattus norvegicus
5 CONCLUSION: We demonstrated that daily sildenafil administration can restore the impaired VEGF system in the penis of DMED rats and progressively improve both erectile function and endothelial function, suggesting a potential general mechanism of improved signaling through the VEGF/eNOS signaling cascade. Sildenafil Citrate vascular endothelial growth factor A Rattus norvegicus