Title : Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis.

Pub. Date : 2010 May 15

PMID : 20478997






2 Functional Relationships(s)
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1 Using different combinations of genetically modified mice, we demonstrate that Nrf2 activates the production, recycling, and release of glutathione and cysteine by suprabasal keratinocytes, resulting in protection of basal cells in a paracrine, glutathione/cysteine-dependent manner. Cysteine nuclear factor, erythroid derived 2, like 2 Mus musculus
2 Using different combinations of genetically modified mice, we demonstrate that Nrf2 activates the production, recycling, and release of glutathione and cysteine by suprabasal keratinocytes, resulting in protection of basal cells in a paracrine, glutathione/cysteine-dependent manner. Cysteine nuclear factor, erythroid derived 2, like 2 Mus musculus