Title : Angiotensin II receptor blocker telmisartan enhances running endurance of skeletal muscle through activation of the PPAR-δ/AMPK pathway.

Pub. Date : 2011 Jul

PMID : 20477906






2 Functional Relationships(s)
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1 Administration of telmisartan up-regulated levels of PPAR-delta and phospho-AMPKalpha in cultured myotubes. Telmisartan peroxisome proliferator activator receptor delta Mus musculus
2 Chronic administration of telmisartan remarkably prevented weight gain, enhanced running endurance and post-exercise oxygen consumption, and increased slow-twitch skeletal muscle fibres in wild-type mice, but these effects were absent in PPAR-delta-deficient mice. Telmisartan peroxisome proliferator activator receptor delta Mus musculus